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KMID : 0381120060280040369
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Genes and Genomics
2006 Volume.28 No. 4 p.369 ~ p.373
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Absence of the C-C Chemokine Receptor-5 Polymorphism in a Korean Population
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Kim Jeong-Joong
Lee Jae-Hoon
Min Jung-Youl
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Abstract
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RANTES is a chemokine known to play an important role in the pathogenesis of allergic rhinitis. The C-C chemokine receptor (CCR5) is the receptor of RANTES, MIP-1α, and MIP-1�� . T cells from CCR5Δ32 (a 32-bp deletion in the CCR5 gene) homozygotes secreted RANTES levels that were 20-fold higher than those of control CCR5 homozygous cells. We hypothesized that the CCR5Δ32 allele might play a role in susceptibility to allergic rhinitis. Using case-control analysis, we evaluated the association between the CCR5Δ32 polymorphism and allergic rhinitis in a Korean population. Blood samples for genetic analysis were obtained from 187 individuals with allergic rhinitis and from 278 healthy subjects without atopic diseases. A polymerase chain reaction-based assay for the CCR5 gene polymorphism was used for genotyping. We were unable to find any CCR5Δ32 homozygotes or heterozygotes in either the control group or allergic rhinitis patients. Since the frequency of the CCR5Δ32 allele did not deviate from the healthy control population, it is unlikely that this allele influences predisposition to allergic rhinitis among Koreans.
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KEYWORD
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Allergic rhinitis, C-C chemokine receptor 5, Korean population, polymorphism
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